Protein Plays Unexpected Role in Blood Cholesterol Levels
Kinesins are motor proteins that “walk” along microtubules and transport various cargoes throughout the cell. A study in The Rockefeller Univ. Press’ The Journal of Cell Biology uncovers an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the blood.
Researchers from The Univ. of Tokyo in Japan studied mice lacking KIF13B, one of 45 kinesins in the human genome. KIF13B is particularly abundant in the liver, and KIF13B mutant mice were found to have elevated levels of cholesterol in their blood.
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