Controlling Triggers of Inflammation Could Extend ‘Healthspan’
Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer’s, and diabetes. But according to a Yale Univ. study, even in the absence of a disease, inflammation can lead to serious loss of function throughout the body, reducing healthspan — that portion of our lives spent relatively free of serious illness and disability.
Published as the cover article in the October issue of Cell Metabolism, the study found that immune sensor Nlrp3 inflammasome is a common trigger of this inflammation-driven loss of function that manifests itself in insulin-resistance, bone loss, frailty and cognitive decline in aging.
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