Chip “Sees” in 3D to Diagnose HIV, Leukemia
Inexpensive, portable devices that can rapidly screen cells for leukemia or HIV may soon be possible thanks to a chip that can produce three-dimensional focusing of a stream of cells, according to researchers. “HIV is diagnosed based on counting CD4 cells,” says Tony Jun Huang, associate professor of engineering science and mechanics at Penn State. “Ninety percent of the diagnoses are done using flow cytometry.”
Huang and his colleagues designed a mass-producible device that can focus particles or cells in a single stream and performs three different optical assessments for each cell. They believe the device represents a major step toward low-cost flow cytometry chips for clinical diagnosis in hospitals, clinics and in the field.
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